Selection of a Macaque Fab with Framework Regions Like Those in Humans, High Affinity, and Ability To Neutralize the Protective Antigen (PA) of Bacillus anthracis by Binding to the Segment
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چکیده
Selection of a Macaque Fab with Framework Regions Like Those in Humans, High Affinity, and Ability To Neutralize the Protective Antigen (PA) of Bacillus anthracis by Binding to the Segment of PA between Residues 686 and 694 Emmanuelle Laffly, Ludivine Danjou, Florence Condemine, Dominique Vidal, Emmanuel Drouet, Marie-Paule Lefranc, Chantal Bottex, and Philippe Thullier* EA 2939 GDR CNRS, Virologie moléculaire et structurale, La Tronche, France; Département de biologie des agents transmissibles, Centre de Recherche du Service de Santé des Armées, La Tronche, France; and Laboratoire d’ImmunoGénétique Moléculaire (LIGM), Université Montpellier II, UPR CNRS 1142, Institut de Génétique Humaine (IGH), Montpellier, France, and Institut Universitaire de France, Paris, France
منابع مشابه
Construction of a Eukaryotic Plasmid Encoding Bacillus anthracis Protective Antigen, a Candidate for DNA Vaccine
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Protective antigen (PA), a subunit of anthrax toxin from Bacillus anthracis, is known as a dominant component in subunit vaccines in protection against anthrax. In order to avoid the side effects of live attenuated and killed organisms, the use of linear neutralizing epitopes of PA is recommended in order to design recombinant vaccines. The present study is aimed at determining the dominant epi...
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